Silicosis is a serious
disease caused by inhalation of crystalline silica
particles. The most common industrial exposures to
crystalline silica occur in mining, rock drilling,
stonework and quarrying, foundry work, sandblasting,
glass blowing, and pottery making. This article will
focus on the requirements for medical surveillance of
silica workers and the need for education of workers and
their employers to reduce the incidence of this
preventable disease.
Silica
Oxygen
is the most abundant element in the earth’s crust.
Silicon is the second most abundant element. With so
much of each of these elements around, you just know
they are going to interact. Silica is made up of one
atom of silicon and two atoms of oxygen. Silica can be
free, unbound to other minerals, such as quartz, chert,
flint, opal and diatomite. If the silica is combined
with other minerals, the combined forms are called
silicates, which include substances such as asbestos and
talc. Amorphous silica is non-crystalline and does not
cause silicosis. If the silica molecules are lined up in
an orderly, repeated pattern, the silica is crystalline
in form. There are several types of crystalline silica
depending on the type of repeated pattern in the
molecular chains. Quartz is the most common crystalline
silica in the environment, occurring as sand and as a
component of many rocks. The crystalline forms of silica
are formed from heating quartz or amorphous silica. The
heat con-version of amorphous silica to crystalline
silica occurs frequently in industries such as
foundries. Cristobalite and tridymite can occur from
this conversion, and are much more fibrogenic than
quartz.
Silicosis
Silicosis is the disease that may be caused by
inhalation of crystalline silica particles of respirable
size. The interaction of crystalline silica and alveolar
macrophages leads to the fibrosis that is characteristic
of silicosis. The development of fibrosis takes time.
For most exposures the average time for development of
fibrosis is about 20 years. Acute silicosis from massive
short-term exposure is the exception. The most common
symptoms of silico-sis are: dyspnea with exercise,
fatigue, fever, weight loss, loss of appetite, mild
cyanosis of the lips and ear lobes. The three types of
silicosis — chronic, accelerated and acute — are
determined by the intensity of the exposure to
crystalline silica. Silicosis is characterized by the
chest radiographic findings. Chronic silicosis may be
simple chronic silicosis or conglomerate silicosis, also
known as Progressive Mas-sive Fibrosis (PMF). In simple
silicosis the chest x-ray shows small, discrete radio
opacities that are less than 10 mm in diameter and
predominantly occur in the upper lung zones. Typically,
lung function is normal in simple silicosis. There may
be mild abnormalities in forced ex-piratory flow.
However, there is rarely any disability. In PMF, also
known as conglomerate silicosis, the small opacities
coalesce into large opacities greater than 10 mm in
diameter. Those opacities are most predomi-nant in the
upper lung fields. Advanced conglomerate silicosis
produces a characteristic butterfly-shaped opac-ity in
the upper lung areas. Chronic silicosis occurs after 10
or more years of mild exposure and the radiographic
changes may not be apparent until after 15 years of
exposure to silica. Hilar adenopathy is common. The
hilar nodes may be outlined with a thin shell of cal-cium.
This eggshell calcification is highly suggestive of
silicosis. Once conglomerate lesions are present, lung
function becomes impaired and further deterioration may
be rapid. Accelerated silicosis develops within 10 years
of ini-tial exposure to more intense levels of silica.
Symptoms may be absent or be mild, presenting with
chronic cough and dyspnea, but may become severe with
the development of PMF. Radiologic findings appear
between 5 and 15 years of exposure showing the same
pattern as chronic silicosis.
Acute silicosis
occurs within weeks to a few years after massive
exposure to crystalline silica. Acute silicosis is
generally fatal. In acute silicosis, the radiographic
appearance is of basilar alveolar proteinosis and occurs
from short-term overwhelming exposure to free
crystalline silica.
Associated
Conditions
The
increased risk of tuberculosis in individuals with
silicosis has been recognized since the 16th century.
This increased risk of infection also applies to other
mycobacterial infections. The increased prevalence of
tuberculosis in populations of individuals with
silicosis has been reported to range from 5% to 75%.
Since there is increased incidence and prevalence of
tuberculosis in the presence of silicosis, surveillance
for tuberculosis is a necessary part of the medical
surveillance of silica-exposed workers.
The association of
silicosis with pulmonary carcinoma remains
controversial. There is an association between silicosis
and autoimmune disease reflected by an increased
incidence of connective tissue disease such as
scleroderma.
Smoking markedly increases
the pulmonary injury of silicosis.
Exposure Limits
The current OSHA permissible exposure
limit (PEL) for general industry, 10 mg/m3 divided by (%
silica quartz + 2) as respirable dust, is based on a
formula recommended by the American Conference of
Governmental Industrial Hygienists (ACGIH) in 1971. The
PEL for construction and maritime was based on particle
counting technology (from the ACGIH’s 1962 Threshold
Limit Value), which is now considered obsolete.
Granite workers in
environments that were carefully monitored and found to
be consistently below the exposure limit of 0.1 mg/m3,
have, over time, developed radiographic lesions
consistent with silicosis.1 Together with the results of
similar studies,2,3 these led NIOSH to establish a lower
recommended exposure limit (REL) of 0.05 mg/m3.
Currently, the American
Conference of Governmental Industrial Hygienists also
recommends a threshold limit value (TLV) of 0.05 mg/m3
for respirable crystalline silica.
Medical Surveillance
Prevention of silicosis is the
paramount goal for silica-exposed workers, because
silicosis is 100 percent preventable. While primary
prevention through exposure control to silica is
critical, medical surveillance of exposed workers plays
an equally important role in prevention and early
detection. It is vital to insist on the use of
respiratory protection, even when respirable crystalline
silica levels in the air are low. Engineering controls
and improved industrial hygiene have lowered the number
of affected people; however, there is still a
significant incidence of silicosis. Individuals with
potential exposure to silica need to be provided with
appropriate respiratory protection and the requirements
of the OSHA Respiratory Protection Standard must be met.
The mandatory OSHA Respirator Medical Evaluation
Questionnaire must be administered prior to the use of
the respirator and fit testing is required.
Re-evaluation and repeated fit testing can be ordered by
the physician if deemed necessary.
The surveillance
recommendations I provide in this article are similar to
OSHA’s Special Emphasis Program on Silicosis but are
more conservative and cautious. Medical surveillance for
silica exposure includes:
1.
Respiratory protection review
of the mandatory OSHA Respirator
Questionnaire:4 The OSHA respirator questionnaire is an
excellent tool for monitoring the crystalline
silica-exposed workforce and covers the majority of the
questions that would be pertinent to silica exposure. It
is not necessary to edit or alter the OSHA Respirator
Questionnaire. The questionnaire must be completed and
reviewed at the time of placement and should be repeated
at least every two years, independent of the
individual’s years of potential exposure.
2.
Review of specific silica exposure
history:
The worker’s comprehensive occupational
and health history should be reviewed at the time of
placement. In addition, the history obtained should
specifically address weight loss, fever, and loss of
appetite.5
3.
Repeat review:
Review of specific silica exposure
history and review of silicosis symptoms not covered by
the OSHA respirator questionnaire should be repeated at
the same interval as for the OSHA respirator
questionnaire, at least every two years.
4.
Physical examination:
A baseline physical examination should
be completed at the time of placement with emphasis on
the respiratory system. The physical examination should
be repeated:
a. if
respiratory symptoms develop;
b. if
interval pulmonary function tests or respirator or
silica questionnaires indicate the need for further
evaluation;
c.
every 5 years for individuals who have had less than 20
years of exposure;
d.
every 2 years for individuals with 20 or more years of
exposure;
e. at
the time of exit from work with exposure to crystalline
silica.
5.
Spirometry:
Pulmonary function decline is seen in
silica-exposed individuals even before there are
radiographic findings. Pulmonary function studies need
to be obtained:
a. at
placement;
b. if
respiratory symptoms develop;
c. if
interval histories indicate a need for further
evaluation;
d.
every 5 years for individuals with less than 20 years of
exposure;
e.
every 2 years for individuals with 20 or more years of
exposure.
6.
Chest x-ray:
Chest x-rays should be obtained at the
time of placement. Repeat chest x-rays would be
appropriate every 5 years for individuals with less than
20 years of exposure and every 2 years for individuals
with 20 or more years of exposure. If questionnaires,
pulmonary function tests or symptoms indicate, then the
chest x-ray should be repeated. There should also be a
repeat chest x-ray at the time of exit.
7.
Surveillance for tuberculosis:
Individuals with known silicosis and those who have had
10 or more years of exposure to crystalline silica
should have annual PPD skin test for tuberculosis. In
this population 10 mm of in duration is considered
positive.
Non-compliance with current standards is very common
among miners, construction workers, foundry workers,
sand blasters, and the stone products industries. This
is where the occupational health professionals need to
recognize their very important role in educating
employers and workers about the risks of silica
exposure. We need to take on the duty of oversight to
assure that the appropriate environmental monitoring is
done, the medical surveillance program is in place, and
employers and workers comply with what we know will
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